A major treatment for corona that benefits males more than women

 
INA-Sources
 
With his second birthday approaching, the new Corona virus is still causing controversy in the world.
 
A new study from the Canadian University of Calgary showed that “dexamethasone”, which is the main treatment for severe lung infections from Covid 19, changes the way immune cells work, in a way that helps male patients more than females.
 
The important finding came as a result of a multidisciplinary study published in Nature Communications, led by Dr. Jeff Bernaske, Professor of Comparative Biology and Experimental Medicine in the College of Veterinary Medicine, and Dr. Brian Yip, Professor of Critical Care Medicine.
 
Limited benefit for women
 
The study found that males benefited from dexamethasone, while females received limited benefit, and the fact that the basic treatment of severe Covid-19 that we provide to everyone only benefits half the population, this is a major problem.
 
He also added that steroids such as dexamethasone were the first drugs identified for severe illness, but that they had only been moderately successful in reducing deaths, and exactly what they did was not understood.
 
 
Surprise.. a major treatment for corona that benefits males more than women!Surprise.. a major treatment for corona that benefits males more than women!
With his second birthday approaching, the new Corona virus is still causing controversy in the world.
 
A new study from the Canadian University of Calgary showed that “dexamethasone”, which is the main treatment for severe lung infections from Covid 19, changes the way immune cells work, in a way that helps male patients more than females.
 
The important finding came as a result of a multidisciplinary study published in Nature Communications, led by Dr. Jeff Bernaske, Professor of Comparative Biology and Experimental Medicine in the College of Veterinary Medicine, and Dr. Brian Yip, Professor of Critical Care Medicine.
 
Limited benefit for women
 
The study found that males benefited from dexamethasone, while females received limited benefit, and the fact that the basic treatment of severe Covid-19 that we provide to everyone only benefits half the population, this is a major problem.
 
He also added that steroids such as dexamethasone were the first drugs identified for severe illness, but that they had only been moderately successful in reducing deaths, and exactly what they did was not understood.
 
And no one knew how immune cells would react to COVID-19 infection at the cellular level, and why some people really get sick while others don’t? Why do some drugs help some and not others?
 
Samples of as many as possible
 
The researchers also used the latest single-cell RNA sequencing and bioinformatics technologies to analyze the functional states of thousands of immune cells from each patient simultaneously, and this allowed them to document cellular behaviors at different stages of the disease, including those with or without Covid-19 infection, and to measure the effects of treatment. , in which samples were taken from as many patients as possible, not only at one time but at the time of follow-up, so that we could get an idea of disease progression and the progression of the immune response.
 
Although, in most cases of viral infections, proteins called interferon work to remove the virus quickly, but with Covid-19 instead of working quickly, the interferon response appears little by little, which actually leads to igniting the flames of inflammation, and then causing damage Members worse.
 
The researcher added that the study found an exaggerated response to interferon in males, which is greatly restricted when the patient is given dexamethasone.
 
As for females, compared to males, the response to interferon was more moderate, so dexamethasone had little effect.
 
After identifying the reasons for a sex bias in the way dexamethasone works, researchers believe the way forward is for science to discover how to make treatments that benefit more people, or individual treatments, also known as precision or personalized medicine, so that no one treatment is used for everyone. Thus, the path of the search for treatment will enter a new tunnel, in which we do not know where the end will be.